Drug Transporters in Drug Disposition, Effects and Toxicity

Cheaper in another edition — £143.50 at Springer Nature Link Shop Drug Transporters in Drug Disposition, Effects and Toxicity · See that edition →

This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presentsa number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and…

The cheapest new copy of Drug Transporters in Drug Disposition, Effects and Toxicity is £179.99 at Springer Nature Link Shop. Prices checked 3 Nov 2026

Other editions

More by Xiaodong Liu

More by Xiaodong Liu